Proteinase K resistant cores of prions and amyloids.
作者: Kushnirov Vitaly VDergalev Alexander AAlexandrov Alexander I
作者单位: 1Research Center of Biotechnology of Russian Academy of Sciences, A.N. Bach Institute of Biochemistry, Moscow, Russia.
刊名: Prion, 2020, Vol.14 (1), pp.11-19
来源数据库: PubMed Journal
DOI: 10.1080/19336896.2019.1704612
关键词: AmyloidPrionPrion variantsProteinase KProteinase resistant coreYeast prions
原始语种摘要: Amyloids and their infectious subset, prions, represent fibrillary aggregates with regular structure. They are formed by proteins that are soluble in their normal state. In amyloid form, all or part of the polypeptide sequence of the protein is resistant to treatment with proteinase K (PK). Amyloids can have structural variants, which can be distinguished by the patterns of their digestion by PK. In this review, we describe and compare studies of the resistant cores of various amyloids from different organisms. These data provide insight into the fine structure of amyloids and their variants as well as raise interesting questions, such as those concerning the differences between amyloids obtained ex vivo and in vitro , as well as the manner in which folding of one region of the amyloid...
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来源刊物:
影响因子:2.133 (2012)

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关键词翻译
关键词翻译
  • resistant 耐久的
  • proteinase 朊酶
  • amyloid 淀粉状朊
  • fibrillary 原纤的
  • Yeast 酵母
  • their 他们的
  • structural 构造
  • insight 识别力
  • provide 规定
  • compare 比较