Protective effects of melatonin on the activity of SOD, CAT, GSH-Px and GSH content in organs of mice after administration of SNP.
作者: Goc ZofiaSzaroma WaldemarKapusta EdytaDziubek Karol
作者单位: 1Department of Animal Physiology and Toxicology, Institute of Biology, Pedagogical University of Cracow, Podbrzezie 3, 31-054 Cracow, Poland.
刊名: The Chinese journal of physiology, 2017, Vol.60 (1)
来源数据库: PubMed Journal
DOI: 10.4077/CJP.2017.BAF435
关键词: catalaseglutathione peroxidasemelatoninreduced glutathionesodium nitroprussidesuperoxide dismutase
原始语种摘要: Sodium nitroprusside (SNP) is an antihypertensive drug with proven dose-dependent toxiceffects attributed mainly to the production of cyanide but also excesive nitric oxide (NO) and derivedreactive species. The present study evaluated whether melatonin administration would have time-dependentprotective effect against SNP−induced toxicity. Male Swiss mice were used in this study.Control mice were treated with 0.9% NaCl; the second group was injected with 10 mg melatonin(MEL)/kg body weight (b.w.); the third group was given SNP at the dose of 3,6 mg/kg b.w.; the fourthgroup received both MEL and SNP at the same doses. In homogenates of brain, liver and kidneys,activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) wereestimated after 3, 6 and 24 h of...
全文获取路径: PubMed  (合作)
影响因子:0.748 (2012)

  • organs 男生殖器
  • administration 管理
  • CAT CATalog
  • GSH 谷胱甘肽
  • melatonin 褪黑激素
  • after 在之后
  • observed 观察到的
  • activity 活度
  • increased 增加
  • SOD Superintendent Of Documents