Cardiorespiratory alterations in rodents experimentally envenomed with Hadruroides lunatus scorpion venom.
作者: Costal-Oliveira FernandaGuerra-Duarte ClaraOliveira Maira SouzaCastro Karen Larissa Pereira deLopes-de-Sousa LeticiaLara AlineGomes Enéas Ricardo de MoraisBonilla CesarGuatimosim SílviaMelo Marília MartinsChávez-Olórtegui Carlos
作者单位: 1Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, CP: 486 CEP: 31270-901 MG Brazil.
2College of Veterinary Medicine, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
3Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG Brazil.
4Instituto Nacional de Salud, Universidad Nacional Mayor de San Marcos y Universidad Científica del Sur, Lima, Peru.
刊名: The journal of venomous animals and toxins including tropical diseases, 2017, Vol.23 , pp.2
来源数据库: PubMed Journal
DOI: 10.1186/s40409-016-0076-5
关键词: Calcium transientCardiorespiratory alterationsElectrocardiographyHadruroides lunatus venomImmunofluorescence
原始语种摘要: Hadruroides lunatus is the most abundant scorpion species in the Peruvian central coast, where most of the accidents involving humans are registered. In spite of its prevalence, there are only very few studies on H. lunatus envenomation. The aim of the present study was to analyze the cardiorespiratory alterations caused by H. lunatus envenomation in rodents.;;Wistar rats injected with H. lunatus scorpion venom were submitted to electrocardiography. After euthanasia, rat lungs were collected and histopathologically analyzed. Mouse cardiomyocytes were used to perform immunofluorescence and calcium transient assays. Data were analyzed by ANOVA or Student's t-test. The significance level was set at p < 0.05.;;It was observed that H. lunatus venom increased heart rate and caused arrhythmia,...
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关键词翻译
关键词翻译
  • scorpion 虫歇
  • venom 毒物
  • rodents 啮齿类
  • envenomation 表面变质
  • arrhythmia 心律不齐
  • transient 瞬变现象
  • importance 重要性
  • central 中心的
  • calcium 
  • inducing 施感的