The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ<sub>25-35</sub>-induced Alzheimer's disease rat model via the AKT/GSK-3β pathway.
作者: Sun YueshanWu AnguoLi XiuQin DalianJin BingjinLiu JianTang YongWu JianmingYu Chonglin
作者单位: 1Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.
2Institute of Cardiovascular Research, The Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou, China.
3Department of Anatomy and Histology and Embryology, Chengdu Medical College, Chengdu, China.
4Department of Human Anatomy, Chengdu Medical Collage, Chengdu, China.
5Institute of Cardiovascular Research, The Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou
刊名: Pharmaceutical biology, 2020, Vol.58 (1), pp.35-43
来源数据库: PubMed Journal
DOI: 10.1080/13880209.2019.1697298
关键词: ADAKTGSK-3βLitchi chinensis seed fractionBeta-amyloidBotanical drugCognitive functionNeuroprotectionTau
原始语种摘要: Context: The seed of Litchi chinensis Sonn., a famous traditional Chinese medicine, was recently reported to enhance cognitive function by inhibiting neuronal apoptosis in rats. Objective: We determined whether the seed of Litchi chinensis fraction (SLF) can ameliorate hippocampal neuronal injury via the AKT/GSK-3β pathway. Materials and methods: We established Alzheimer's disease (AD) model by infusing Aβ25-35 into the lateral ventricle of Sprague-Dawley (SD) rats and randomly divided into five groups ( n = 10): sham, donepezil and SLF (120, 240 and 480 mg/kg/d). Rats were treated by intragastric administration for 28 consecutive days. Spatial learning and memory were evaluated with Morris water maze, while protein expression of AKT, GSK-3β and tau in the hippocampal neurons...
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • pathway 轨道
  • fraction 分数
  • neuronal 二乙基溴乙酰胺
  • platform 台地
  • injury 损害
  • protein 蛋白质
  • amyloid 淀粉状朊
  • administration 管理
  • whether 是否
  • expression 表示