|作者：||Al-Omair Mohammed A., Sedky Azza, Ali Awatef, Elsawy Hany|
1Chemistry Department, College of Science, King Faisal University, Al-Ahsaa, King Saudi Arabia.
2Zoology Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
3Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
|刊名：||The Chinese journal of physiology, 2017, Vol.60 (1)|
|关键词：||blood; lead acetate toxicity; quercetin; testicular alteration;|
|原始语种摘要：||Lead is one of the oldest environmental and occupational toxins. Health hazards from increasedlead exposure as a result of industrial and environmental pollution are recognized. The aim of the presentstudy was to investigate the protective effects of quercetin as a model of an antioxidant drug againstthe toxic effects of lead acetate on the blood and the testis of rats. The lead concentrations were determined inblood and the testis. Testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH)were assessed in serum. Hemoglobin (Hb) content, packed cell volume (PCV), white blood cell (WBC)and red blood cell (RBC) counts were evaluated in the whole blood. Our results showed that administration oflead acetate was associated with an increased lead levels in blood as well... as in the testis. Lead acetateadministration also caused a decrease in testicular function, Hb content, PCV and RBC count in comparison tothe respective mean values of the control. In addition, lead acetate increased WBC count and inducedalterations in sperm count, sperm motility and sperm abnormality and histopathology. In the contrary,administration of lead acetate along with quercetin partially restored the studied parameters to normal values.In conclusion, the treatment with quercetin may provide a partial protection against the toxic effectsinduced by lead acetate in blood and the testis of rats.|