Regulation of blood glucose level by kainic acid in mice: involvement of glucocorticoid system and non-NMDA receptors.
作者: Kim Chea-HaPark Soo-HyunSim Yun-BeomKim Sung-SuJung Jun-SubSharma NaveenSuh Hong-Won
作者单位: 1Department of Pharmacology, Institute of Natural Medicine, College of Medicine Hallym University, 39 Hallymdaehak-gil, Chuncheon, Gangwon-do 200-702, Republic of Korea.
刊名: The Chinese journal of physiology, 2017, Vol.60 (1)
来源数据库: PubMed Journal
DOI: 10.4077/CJP.2017.BAE397
关键词: CNQXglucocorticoidhyperglycemiakainic acidspinalsupraspinal
原始语种摘要: Kainic acid (KA) is a well-known excitatory neurotoxic substance. In the present study, effectsof KA-injected intraperitoneally (i.p.), intracerebroventricularly (i.c.v.) or intrathecally (i.t.) on theblood glucose level were investigated in ICR mice. We found that KA administered intraperitoneally(i.p.), intracerebroventricularly (i.c.v.) or intrathecally (i.t.) increased the blood glucose and corticosteronelevels, suggesting that KA-induced hyperglycemia appeared to be due to increased blood corticosteronelevel. In support of this finding, adrenalectomy causes a reduction of KA-induced hyperglycemia andneuronal cell death in CA3 regions of the hippocampus. In addition, pretreatment with i.c.v. or i.t. injectionof CNQX (6-cyano-7-nitroquinoxaline-2, 3-dione; a non-NMDA receptor blocker)...
全文获取路径: PubMed  (合作)
影响因子:0.748 (2012)

  • glucose 葡萄糖
  • glucocorticoid 糖皮质激素
  • hyperglycemia 高血糖
  • induced 感应的
  • pretreatment 预处理
  • level 水准
  • corticosterone 皮质甾酮
  • responsible 负责的
  • plasma 深绿玉髓
  • adrenalectomy 肾上腺切除术