Immune Activation in the Liver by Nucleic Acids.
作者: Sun QianWang QingdeScott Melanie JBilliar Timothy R
作者单位: 1Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
刊名: Journal of clinical and translational hepatology, 2016, Vol.4 (2), pp.151-7
来源数据库: PubMed Journal
DOI: 10.14218/JCTH.2016.00003
关键词: HepatocytesInnate immunityIntracellular receptorNucleic acid
原始语种摘要: Viral infection in the liver, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, is a major health problem worldwide, especially in developing countries. The infection triggers a pro-inflammatory response in patients that is crucial for host defense. Recent studies have identified multiple transmembrane and cytosolic receptors that recognize pathogen-derived nucleic acids, and these receptors are essential for driving immune activation in the liver. In addition to sensing DNA/RNA from pathogens, these intracellular receptors can be activated by nucleic acids of host origin in response to sterile injuries. In this review, we discuss the expanding roles of these receptors in both immune and nonimmune cells in the liver.
全文获取路径: PubMed  (合作)

  • liver 
  • worldwide 世界的
  • hepatitis 肝炎
  • transmembrane 横跨膜的
  • developing 显影
  • immune 免疫的
  • infection 感染
  • crucial 有决定性的
  • response 响应
  • essential 本质的