Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update.
作者: Yoon EricBabar AroojChoudhary MoazKutner MatthewPyrsopoulos Nikolaos
作者单位: 1Rutgers New Jersey Medical School, University Hospital, Newark, New Jersey, USA.
刊名: Journal of clinical and translational hepatology, 2016, Vol.4 (2), pp.131-42
来源数据库: PubMed Journal
DOI: 10.14218/JCTH.2015.00052
关键词: APAPAcetaminophen toxicityAcute liver failure (ALF)HepatotoxicityParacetamol
原始语种摘要: Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within hepatocytes. APAP hepatotoxicity remains a global issue; in the United States, in particular, it accounts for more than 50% of overdose-related acute liver failure and approximately 20% of the liver transplant cases. The pathophysiology, disease course and management of acute liver failure secondary to APAP toxicity remain to be precisely elucidated, and adverse patient outcomes with increased morbidity and mortality continue to occur. Although APAP hepatotoxicity follows a predictable timeline of hepatic failure, its clinical presentation might...
全文获取路径: PubMed  (合作)

  • overdose 过剂量
  • hepatotoxicity 肝毒性
  • liver 
  • antidotal 有解毒功效的
  • remains 残渣
  • acetylcysteine 乙酰半胱胺酸
  • intentional 有意的
  • secondary 二次的
  • failure 破坏
  • acetaminophen 醋胺酚