Brain Iron Distribution after Multiple Doses of Ultra-small Superparamagnetic Iron Oxide Particles in Rats.
作者: Gorman Andrew WDeh Kofi MSchwiedrzik Caspar MWhite Julie RGroman Ernest VictorFisher Clark AGillen Kelly MSpincemaille PascalRasmussen SkyePrince Martin RVoss Henning UFreiwald Winrich AWang Yi
作者单位: 1Institute of Comparative Medicine, Columbia University, New York, New York and Center of Comparative Medicine and Pathology, Memorial Sloan-Kettering Center, Tri Institutional Training Program in Laboratory Animal Medicine and Science, New York, New York;, Email: ag3825@columbia.edu.
2Joan and Sanford I Weill Medical College, Cornell University, New York, New York.
3Laboratory of Neural Systems, Rockefeller University, New York, New York, and Neural Circuits and Cognition Lab, European Neuroscience Institute, Gottingen, Germany.
4Center of Comparative Medicine and Pathology, Memorial Sloan-Kettering Cancer Center, Tri Institutional Training Program in Laboratory Animal Medicine and Science, New York, New York.
5Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado.
6Laboratory of Neural Systems, Rockefeller University, New York, New York.
7Joan and Sanford I Weill Medical College, Corne
刊名: Comparative medicine, 2019, Vol.68 (2), pp.139-147
来源数据库: PubMed Journal
原始语种摘要: The purpose of this study is to determine the effects of high cumulative doses of ultra-small paramagnetic iron oxide (USPIO) used in neuroimaging studies. We intravenously administered 8 mg/kg of 2 USPIO compounds daily for 4 wk to male Sprague-Dawley rats (Crl:SD). Multiecho gradient-echo MRI, serum iron levels, and histology were performed at the end of dosing and after a 7-d washout period. R2* maps and quantitative susceptibility maps (QSM) were generated from multiecho gradient-echo data. R2* maps and QSM showed iron accumulation in brain ventricles on MR images acquired at the 4- and 5-wk time points. Estimates from QSM data showed ventricular iron concentration was equal to or higher than serum iron concentration. Histologic analysis revealed choroid plexus hemosiderosis and...
全文获取路径: PubMed  (合作)
分享到:
来源刊物:
影响因子:1.12 (2012)

×
关键词翻译
关键词翻译
  • washout 冲蚀
  • dosing 配量
  • multiecho 多次回波
  • brain 
  • cumulative 累积的
  • hemosiderosis 含铁血黄素沉着
  • situation 立场
  • concentration 浓度
  • small 小的
  • susceptibility 磁化率