Nonalcoholic Lipid Accumulation and Hepatocyte Malignant Transformation.
作者: Gu JuanjuanYao MinYao DengbingWang LiYang XuliYao Dengfu
作者单位: 1Research Center of Clinical Medicine and Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
2Department of Immunology, Medical School of Nantong University, Nantong, Jiangsu, China.
3School of Life Sciences, Nantong University, Nantong, Jiangsu, China.
4Department of Medical Informatics, Medical School of Nantong University, Nantong, Jiangsu, China.
刊名: Journal of clinical and translational hepatology, 2016, Vol.4 (2), pp.123-30
来源数据库: PubMed Journal
DOI: 10.14218/JCTH.2016.00010
关键词: Hepatocellular carcinomaMetabolismNonalcoholic fatty liver disease
原始语种摘要: Worldwide incidence of hepatocellular carcinoma (HCC) is steadily increasing, highlighting its status as a public health concern, particularly due to its significant association with other comorbidities, such as diabetes. However, nonalcoholic fatty liver disease (NAFLD) has emerged as a primary risk factor, with its own prevalence increasing in recent years, and it has gradually caught up with the historical primary etiological factors of infection with hepatitis B virus and hepatitis C virus, exposure to aflatoxin, or alcohol liver disease. The deeply worrisome aspects of all of these high risk factors, however, are their remarkable presence within populations. Systemic and genetic mechanisms involved in the malignant transformation of liver cells, as well as useful biomarkers of early...
全文获取路径: PubMed  (合作)

  • liver 
  • hepatocellular 肝细胞性的
  • aflatoxin 黄曲毒素
  • hepatocyte 肝细胞
  • recent 近来的
  • hepatitis 肝炎
  • carcinoma 癌症
  • malignant 恶性的
  • transformation 变换
  • underlying 下伏的