Temporal and anatomical distribution of 18F-flutemetamol uptake in canine brain using positron emission tomography.
作者: Yun TaesikLee WongukKang Ji-HounYang Mhan-PyoKang Byeong-Teck
作者单位: 1Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 28644, South Korea.
2Department of Nuclear Medicine, Chungbuk National University Hospital, Cheongju, Chungbuk, 28644, South Korea.
3Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 28644, South Korea. kangbt@chungbuk.ac.kr.
刊名: BMC veterinary research, 2020, Vol.16 (1), pp.17
来源数据库: PubMed Journal
DOI: 10.1186/s12917-020-2240-y
关键词: 18F-flutemetamolAmyloidCognitive dysfunction syndromeDogPositron emission tomography
原始语种摘要: BACKGROUND(#br)Positron emission tomography (PET) is increasingly being used as an imaging modality for clinical and research applications in veterinary medicine. Amyloid PET has become a useful tool for diagnosing Alzheimer's disease (AD) in humans, by accurately identifying amyloid-beta (Aβ) plaques. Cognitive dysfunction syndrome in dogs shows cognitive and pathophysiologic characteristics similar to AD. Therefore, we assessed the physiologic characteristics of uptake of 18F-flutemetamol, an Aβ protein-binding PET tracer in clinical development, in normal dog brains, for distinguishing an abnormal state. Static and dynamic PET images of six adult healthy dogs were acquired after 18F-flutemetamol was administered intravenously at approximately 3.083 MBq/kg. For static images, PET data...
全文获取路径: PubMed  (合作)
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影响因子:1.861 (2012)

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关键词翻译
关键词翻译
  • positron 阳电子
  • anatomical 解剖的
  • cingulate 具带的
  • uptake 上风口
  • frontal 额骨
  • brain 
  • cortices 外皮的
  • occipital 后头的
  • PET PagE frame Table
  • tomography 断层x 线摄影