Decorin-mediated inhibition of the migration of U87MG glioma cells involves activation of autophagy and suppression of TGF-β signaling.
作者: Yao TingZhang Chen-GuangGong Ming-TaoZhang MinWang LeiDing Wei
作者单位: 1Department of Medical Genetics and Developmental Biology Capital Medical University Beijing China.
2Department of Biochemistry and Molecular BiologyCapital Medical UniversityBeijingChina; Beijing Key Laboratory for Researches in Cancer Invasion and MetastasisCancer Institute of Capital Medical UniversityBeijingChina.
3Department of Biochemistry and Molecular Biology Capital Medical University Beijing China.
4Department of Neurosurgery Beijing Tiantan Hospital China.
5Department of Biochemistry and Molecular BiologyCapital Medical UniversityBeijingChina; Beijing Key Laboratory for Researches in Cancer Invasion and MetastasisCancer Institute of Capital Medical UniversityBeijingChina; Beijing Institute of Brain DisordersChina.
刊名: FEBS open bio, 2016, Vol.6 (7), pp.707-19
来源数据库: PubMed Journal
DOI: 10.1002/2211-5463.12076
关键词: TGF‐β signalAutophagyDecorinGliomaMigration
原始语种摘要: Decorin (DCN) is a major member of the small leucine-rich proteoglycan (SLRP) family that is critically involved in tumorigenesis and the development of metastasis of cancers, including glioma. Overexpression of DCN was indicated to suppress glioma cell growth. However, the role of DCN in the migration of glioma cells remain elusive. In this study, we found that treatment with exogenous DCN inhibited the adhesion and migration of U87MG glioma cells with down-regulation of TGF-β signaling. DCN also activated autophagy, as indicated by monodansylcadaverine (MDC) staining, increase in LC3 I/LC3 II conversion, and p62/SQSTM1 degradation in U87MG cells. The increased activity of autophagy was found to be connected to the inhibition on glioma cell migration. Knockdown of DCN expression or the...
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • glioma 神经胶质瘤
  • signaling 发信号
  • autophagy 自体消瘦
  • migration 迁移
  • cells 麻风细胞
  • adhesion 粘附
  • inhibition 抑制
  • suppression 抑制
  • DCN Delayed Connector Network
  • activation 活化