reply: Neurobiologyp25 protein in neurodegeneration.
作者: Patrick G. N.Zukerberg L.Nikolic La Monte S.Dikkes P.Tsai L.-H.
作者单位: 1Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
刊名: Nature, 2001, Vol.411 (6839), pp.764-765
来源数据库: PubMed Journal
原始语种摘要: Yoo and Lubec show that the amount of p25 is decreased in the brains they studied from patients with Alzheimer's disease or Down's syndrome. Their results persuaded us to conduct a more extensive survey of the p25/p35 ratio in AD brains (to be published elsewhere), as the number of samples was small in both of our studies (eight AD brains in our original study and six in theirs). After analysing a further 25 AD brains and those from 25 age-matched controls, we found that p25 levels are consistently higher in AD brains and that the difference is statistically significant (Student's t-test). This is in agreement with our original observations, as well as being consistent with earlier reports of increased Cdk5 kinase activity in AD brain and of increased amounts of p25 in an animal model of...
全文获取路径: PubMed  (合作)
影响因子:38.597 (2012)

  • brains 智力
  • elsewhere 在别处
  • original 原图
  • reply 答复
  • published 公布的
  • consistently 一贯地
  • reports 判例汇编
  • agreement 协议
  • statistically 统计地
  • earlier 早期的