Treatment of rhesus monkeys (Macaca mulatta) with intravaginal rings impregnated with either progesterone or norethisterone.
作者: Wadsworth P FHeywood RAllen D GHossack D JSortwell R JWalton R M
刊名: Contraception, 1979, Vol.20 (4), pp.339-51
来源数据库: PubMed Journal
原始语种摘要: The effects of both progesterone- and norethisterone-loaded intravaginal rings were investigated in twenty-five rhesus monkeys for 52 weeks. The intravaginal rings were designed to provide a sustained release of either the human dosage level of the hormone or ten times this level. Untreated placebo rings were used for control purposes. The devices were well retained. With the exception of increased plasma fibrinogen levels in animals treated with norethisterone, no marked differences in either local or systemic toxicity between the progesterone and norethisterone intravaginal rings were apparent. Following insertion of the hormone-treated intravaginal rings, a dose-related decrease in vaginal bleeding was recorded. The vaginal microbial flora were assessed qualitatively and...
全文获取路径: PubMed  (合作)
影响因子:3.09 (2012)

  • norethisterone 诺塞甾酮
  • intravaginal 叶鞘内的
  • rhesus 恒河猴
  • either 任何
  • progesterone 孕酮
  • rings 泥包
  • endocervical 子宫颈内的
  • hormone 激素
  • vagina 叶鞘
  • mucosal 粘膜的