Treatment of rhesus monkeys (Macaca mulatta) with intravaginal rings loaded with levonorgestrel.
作者: Wadsworth P FHeywood RAllen D GHossack D JSortwell R JWalton R M
刊名: Contraception, 1979, Vol.20 (6), pp.559-67
来源数据库: PubMed Journal
原始语种摘要: The effects of levonorgestrel-releasing intravaginal rings were investigated in 15 rhesus monkeys for 52 weeks. The intravaginal rings were designed to provide a sustained release of either three or ten times the human dose level of the hormone. Untreated placebo rings were used as a control. The devices were well retained. After insertion of the vaginal rings, a dose-related decrease in vaginal bleeding was observed. The vaginal microbial flora were assessed qualitatively and semi-quantitatively and although all groups including controls showed some changes in microbial populations, by the end of the study nearly all animals returned to a normal balanced microflora. Terminal studies showed that, at the high dose level, ovulation was suppressed and widespread atrophy of the uterine...
全文获取路径: PubMed  (合作)
影响因子:3.09 (2012)

  • levonorgestrel 左炔诺孕酮
  • intravaginal 叶鞘内的
  • rhesus 恒河猴
  • rings 泥包
  • loaded 加负荷的
  • atrophy 萎缩
  • mucosal 粘膜的
  • glandular 腺的
  • microflora 微植物群
  • endocervical 子宫颈内的