|作者：||Ma Lina, Cao Jiabao, Liu Lin, Li Zhao, Shireen Huma, Pervaiz Nashaiman, Batool Fatima, Raza Rabail Z, Zou Dong, Bao Yiming, Abbasi Amir A, Zhang Zhang|
1BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
2CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
3University of Chinese Academy of Sciences, Beijing, China.
4National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
|刊名：||Current protocols in bioinformatics, 2019, Vol.67 (1), pp.e82|
|关键词：||Community curation; Disease; Expert curation; Long noncoding RNA; Multi-omics data;|
|原始语种摘要：||In recent years, the number of human long noncoding RNAs (lncRNAs) that have been identified has increased exponentially. However, these lncRNAs are poorly annotated compared to protein-coding genes, posing great challenges for a better understanding of their functional significance and elucidating their complex functioning molecular mechanisms. Here we employ both community and expert curation to yield a comprehensive collection of human lncRNAs and their annotations. Specifically, LncRNAWiki (http://lncrna.big.ac.cn/index.php/Main_Page) uses a wiki-based community curation model, thus showing great promise in dealing with the flood of biological knowledge, while LncBook (http://bigd.big.ac.cn/lncbook) is an expert curation-based database that provides a complement to LncRNAWiki. LncBook... features a comprehensive collection of human lncRNAs and a systematic curation of lncRNAs by multi-omics data integration, functional annotation, and disease association. These protocols provide step-by-step instructions on how to browse and search a specific lncRNA and how to obtain a range of related information including expression, methylation, variation, function, and disease association. © 2019 by John Wiley & Sons, Inc.|