Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook.
作者: Ma LinaCao JiabaoLiu LinLi ZhaoShireen HumaPervaiz NashaimanBatool FatimaRaza Rabail ZZou DongBao YimingAbbasi Amir AZhang Zhang
作者单位: 1BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
2CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
3University of Chinese Academy of Sciences, Beijing, China.
4National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
刊名: Current protocols in bioinformatics, 2019, Vol.67 (1), pp.e82
来源数据库: PubMed Journal
DOI: 10.1002/cpbi.82
关键词: Community curationDiseaseExpert curationLong noncoding RNAMulti-omics data
原始语种摘要: In recent years, the number of human long noncoding RNAs (lncRNAs) that have been identified has increased exponentially. However, these lncRNAs are poorly annotated compared to protein-coding genes, posing great challenges for a better understanding of their functional significance and elucidating their complex functioning molecular mechanisms. Here we employ both community and expert curation to yield a comprehensive collection of human lncRNAs and their annotations. Specifically, LncRNAWiki ( uses a wiki-based community curation model, thus showing great promise in dealing with the flood of biological knowledge, while LncBook ( is an expert curation-based database that provides a complement to LncRNAWiki. LncBook...
全文获取路径: PubMed  (合作)

  • functional 功能的
  • community 群落
  • systematic 有系统的
  • expression 表示
  • poorly 贫乏地
  • association 联合
  • recent 近来的
  • comprehensive 全面
  • annotation 注解
  • promise 允诺