STAT3-induced up-regulation of lncRNA NEAT1 as a ceRNA facilitates abdominal aortic aneurysm formation by elevating TULP3.
作者: Cai BingYang BaihuiHuang DongWang DiTian JunChen FeiyunWang Xi
作者单位: 1Cardiovascular Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, China.
刊名: Bioscience reports, 2020, Vol.40 (1)
来源数据库: PubMed Journal
DOI: 10.1042/BSR20193299
关键词: AAANEAT1STAT3TULP3MiR-4688
原始语种摘要: Long noncoding RNAs (lncRNAs) were viewed as crucial participants in the pathogenesis of abdominal aortic aneurysm (AAA). LncRNA NEAT1 was recognized as an oncogenic gene in various diseases. However, its function and mechanism in AAA were not precisely documented. Here, we explored the functional role and molecular mechanism of NEAT1 in AAA. Functionally, the effect of NEAT1 on the proliferation was assessed by CCK-8 and EdU assay, while its impact on the apoptosis was evaluated through caspase-3/9 activity and TUNEL assays. As a result, we found that NEAT1 knockdown enhanced the proliferation and impaired the apoptosis of vascular smooth muscle cells (VSMCs). Reversely, overexpressed NEAT1 exerted anti-proliferation and pro-apoptosis effects in VSMCs. Mechanically, we found that STAT3...
全文获取路径: PubMed  (合作)
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影响因子:1.876 (2012)

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关键词翻译
关键词翻译
  • formation 建造
  • STAT 静止的
  • knockdown 击倒
  • regulation 
  • functional 功能的
  • abdominal 腹部的
  • aortic 织脉的
  • induced 感应的
  • confirmed 已确认的
  • luciferase 荧光素酶