Genetic Characterization of a Novel Reassortant H5N6 Avian Influenza Virus Identified from a 10-Year-Old Girl.
作者: Dong ZefengYa XuerongWang DiLiu ChengShen QiangXia Yu
作者单位: 1Suzhou Center for Disease Prevention and Control.
刊名: Japanese journal of infectious diseases, 2020, Vol.73 (1), pp.36-43
来源数据库: PubMed Journal
DOI: 10.7883/yoken.JJID.2019.101
关键词: Avian influenza virusHemagglutinin (HA)MutationNeuraminidase (NA)Reassortment
原始语种摘要: A 10-year-old girl was confirmed, by laboratory tests, to be infected with the H5N6 subtype of the highly pathogenic avian influenza virus in Suzhou city in November, 2018 (JSSZ01). The hemagglutinin (HA) gene of this H5N6 virus belonged to the H5 clade, and the HA linkage peptide of the JSSZ01 strain was RERRRKR↓GLF with multiple basic amino acids. Q226L and G228S mutations were not observed, but S128P, S137A, and T160A substitutions were identified in the receptor binding sites. The resistance mutation D198N in the neuraminidase (NA) protein was also identified in this strain. Additionally, an 11 amino acid (AA positions 59-69) deletion was identified in the NA stalk region. Most genes of JSSZ01 exhibited highest identity with previously characterized H5N6 viruses, but its PA...
全文获取路径: PubMed  (合作)
影响因子:1.507 (2012)

  • virus 病毒
  • neuraminidase 神经氨酸酶
  • influenza 列性感冒
  • avian 鸟的
  • hemagglutinin 血凝素
  • pathogenic 病原的
  • previously 以前
  • stalk 晶体管管座
  • indicating 指示
  • linkage 连接