Comparison of the effects of terazosin and enalapril on laboratory stress testing blood pressure in patients with essential hypertension.
作者: Cardillo CDegen CCampia UDe Felice FFolli G
作者单位: 1Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Roma, Italy.
刊名: Journal of clinical pharmacology, 1993, Vol.33 (5), pp.433-8
来源数据库: PubMed Journal
原始语种摘要: It is the current opinion that an ideal antihypertensive drug should reduce blood pressure (BP) not only at rest but also during stressful situations. The current study was aimed to compare the effects of the selective alpha 1-adrenergic blocker terazosin (5 mg once daily) and of the angiotensin-converting enzyme inhibitor enalapril (20 mg once daily) on cardiovascular response to a set of standardized laboratory stressors, such as mental arithmetic, handgrip test and cycle ergometry, in a group of 16 essential hypertensive patients. The study was a randomized, double-blind, cross-over trial preceded by a placebo run-in period. Terazosin and enalapril had a comparable effect on resting BP, reducing systolic (SBP) and diastolic (DBP) blood pressure from 159.5 +/- 13.9/101.6 +/- 8.8 mm Hg...
全文获取路径: PubMed  (合作)

  • hypertension 高血压
  • essential 本质的
  • laboratory 实验室
  • pressure 压力
  • handgrip 把手
  • stress 应力
  • hypertensive 高血压的
  • ergometry 测力学
  • converting 转换
  • angiotensin 血管紧张肽