Significance of HER2 protein expression and HER2 gene amplification in colorectal adenocarcinomas.
作者: Wang Xin-YuZheng Zhi-XueSun YuBai Yan-HuaShi Yun-FeiZhou Li-XinYao Yun-FengWu Ai-WenCao Deng-Feng
作者单位: 1Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing 100142, China.
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing 100142, China.
3Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing 100142, China. sunyu_bch@163.com.
4Key laboratory of Carcinogenesis and Translational Research (Ministry of Education)
刊名: World journal of gastrointestinal oncology, 2019, Vol.11 (4), pp.335-347
来源数据库: PubMed Journal
DOI: 10.4251/wjgo.v11.i4.335
关键词: Colorectal cancersFluorescent in situ hybridizationHuman epidermal growth factor receptor 2Immunohistochemical stainingPrognosis
原始语种摘要: BACKGROUND(#br)Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver, and a well-established therapeutic target in breast and gastric cancers. While the role of HER2 as a prognostic biomarker in colorectal adenocarcinomas (CRCs) remains uncertain, its relevance as a therapeutic target has been established. We undertook the present study to evaluate the frequency of HER2 expression in CRC and to correlate it with various clinicopathological variables.(#br)AIM(#br)To correlate HER2 protein expression and HER2 gene amplification with clinicopathological features and survival in surgically resected CRC.(#br)METHODS(#br)About 1195 consecutive surgically resected CRCs were analyzed by immunohistochemical staining (IHC) to assess HER2 protein expression, and 141 selected tumors...
全文获取路径: PubMed  (合作)
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关键词翻译
关键词翻译
  • protein 蛋白质
  • amplification 放大
  • colorectal 结肠直肠的
  • expression 表示
  • survival 生存
  • prognosis 预报
  • therapeutic 治疗的
  • correlated 相关
  • tubular 管状的
  • staining 染色