Prophylactic Vaccine Based on Pyroglutamate-3 Amyloid β Generates Strong Antibody Response and Rescues Cognitive Decline in Alzheimer's Disease Model Mice.
作者: Li GaoHu Zhi-WenChen Pu-GuangSun Zhan-YiChen Yong-XiangZhao Yu-FenLi Yan-Mei
作者单位: 1Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
2Key Laboratory of Bioo
刊名: ACS chemical neuroscience, 2017, Vol.8 (3), pp.454-459
来源数据库: PubMed Journal
DOI: 10.1021/acschemneuro.6b00336
关键词: Alzheimer’s disease (AD)Aβ plaquesProphylactic immunizationPyroglutamate-3 AβVaccine
原始语种摘要: Clearance of amyloid β (Aβ) by immunotherapy is one of the fancy methods to treat Alzheimer's disease (AD). However, the failure of some clinical trials suggested that there may be something ignored in the past development of immunotherapy. Pyroglutamate-3 Aβ (AβpE3-X), which was found to be abundant in the patients' brain, has attracted much attention after the report that AβpE3-42 could serve as a template to exacerbate the aggregation of Aβ. In addition, AβpE3-X could not be recognized by the antibodies targeting the N-terminus of Aβ, suggesting that AβpE3-X maybe the ignored one. Indeed, passive immunization targeting AβpE3-X has shown some beneficial results, while active immunotherapy has not been extensively studied. In the...
全文获取路径: PubMed  (合作)
影响因子:3.871 (2012)

  • immunization 免疫法
  • Vaccine 疫苗程序
  • epitope 抗原决定部位
  • immunotherapy 免疫疗法
  • vaccine 菌苗
  • Antibody 抗体
  • targeting 导向目标
  • prophylactic 预防性的
  • antibody 抗体
  • exacerbate 加重