The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R.
作者: Panni SimonaSalvioli StefanoSantonico ElenaLangone FrancescaStorino FrancescaAltilia SerenaFranceschi ClaudioCesareni GianniCastagnoli Luisa
作者单位: 1Department DiBEST, University of Calabria, Rende, 87036, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna 40126, Italy; CIG, Interdepartmental Center "Luigi Galvani", University of Bologna, Bologna 40126, Italy; Department of Biology, University of Rome Tor Vergata, Rome 00100, Italy; and Istituto Ricovero e Cura a Carattere Scientifico, Fondazione Santa Lucia, Rome, 00100, Italy simona.panni@unical.it.
2Department DiBEST, University of Calabria, Rende, 87036, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna 40126, Italy; CIG, Interdepartmental Center "Luigi Galvani", University of Bologna, Bologna 40126, Italy; Department of Biology, University of Rome Tor Vergata, Rome 00100, Italy; and Istituto Ricovero e Cura a Carattere Scientifico, Fondazione Santa Lucia, Rome, 00100, Italy Department DiBEST, University of Calabria, Rende, 87036, Italy; DIMES, Department of Experimental, Diagnostic and S
刊名: Journal of biochemistry, 2015, Vol.157 (2), pp.101-11
来源数据库: PubMed Journal
DOI: 10.1093/jb/mvu059
关键词: CD2APP72RSH3 domainsP53 polymorphismPolyproline
原始语种摘要: Proline-rich motifs are widely distributed in eukaryotic proteomes and are usually involved in the assembly of functional complexes through interaction with specific binding modules. The tumour-suppressor p53 protein presents a proline-rich region that is crucial for regulating apoptosis by connecting the p53 with a complex protein network. In humans, a common polymorphism determines the identity of residue 72, either proline or arginine, and affects the features of the motifs present in the polyproline domain. The two isoforms have different biochemical properties and markedly influence cancer onset and progression. In this article, we analyse the binding of the p53 proline-rich region with a pool of selected polyproline binding domains (i.e. SH3 and WW), and we present the first...
全文获取路径: PubMed  (合作)
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影响因子:2.719 (2012)

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关键词翻译
关键词翻译
  • protein 蛋白质
  • polyproline 聚脯氨酸
  • polymorphic 多形
  • discriminate 区分
  • region 地域
  • cytoplasm 细胞质
  • eukaryotic 真核的
  • purified 净化的
  • functional 功能的
  • binding 装订