Regulatory B Cell Function Is Suppressed by Smoking and Obesity in H. pylori-Infected Subjects and Is Correlated with Elevated Risk of Gastric Cancer.
作者: Li GuanggangWulan HasiSong ZongchangPaik Paul ATsao Ming LGoodman Gary MMacEachern Paul TDowney Robert SJankowska Anna JRabinowitz Yaron MLearch Thomas BSong David ZYuan Ji JZheng ShihangZheng Zhendong
作者单位: 1Affiliated Bayi Brain Hospital, General Hospital of Beijing Military Command, Beijing, 100700, China.
2Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing, 100853, China.
3Department of Oncology, The 155th Central Hospital of PLA, Kaifeng, 475003, China.
4Roswell Park Cancer Institute, Buffalo, NY, United States of America.
5Georgetown University Medical Center, Washington DC, United States of America.
6University of Maryland Medical Center. Baltimore, MD, United States of America.
7University Hospital, University of British Columbia, Vancouver, BC, Canada.
8University Hospital, University of British Columb
刊名: PloS one, 2015, Vol.10 (7), pp.e0134591
来源数据库: PubMed Journal
DOI: 10.1371/journal.pone.0134591
原始语种摘要: Helicobacter pylori infection occurs in more than half of the world's population and is the main cause for gastric cancer. A series of lifestyle and nutritional factors, such as tobacco smoking and obesity, have been found to elevate the risk for cancer development. In this study, we sought to determine the immunological aspects during H. pylori infection and gastric cancer development. We found that B cells from H. pylori-infected patients presented altered composition and function compared to uninfected patients. IL-10-expressing CD24+CD38+ B cells were upregulated in H. pylori-infected patients, contained potent regulatory activity in inhibiting T cell pro-inflammatory cytokine secretion, and responded directly to H. pylori antigen stimulation. Interestingly, in H. pylori-infected...
全文获取路径: PubMed  (合作)
影响因子:3.73 (2012)

  • gastric 胃的
  • Helicobacter 哈比特属
  • suppressing 制止的
  • cells 麻风细胞
  • Cancer 巨蟹座
  • stimulation 激励
  • potent 强大的
  • reduced 减缩的
  • asymptomatic 无症状的
  • infected 被感染