Reciprocal expression of p-AMPKa and p-S6 is strongly associated with the prognosis of gastric cancer.
作者: Zheng ZhendongZheng YingjuanZhang MeiyanWang JiejunYu GuanzhenFang Wenzheng
作者单位: 1Department of Oncology, Changzheng Hospital, Shanghai, 200070, China.
2Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, 110016, Jilin Province, China.
3Department of Oncology, The 371st Central Hospital, Xinxiang City, 453000, Henan Province, China.
4Department of Internal Medicine, Emergency Center, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
5Department of Oncology, Changzheng Hospital, Shanghai, 200070, China. jiejunw@csco.org.cn.
6Department of Medical Oncology, Shanghai East Hospital, Shanghai, 200120, China. jiejunw@csco.org.cn.
7Department of Oncology, Changzheng Hospital, Shanghai, 200070, China. qiaoshanqian@aliyun.com.
8Department of Medical Oncology, Shanghai East Hospital, Shanghai, 200120, China. qiaoshanqian@aliyun.com.
9Department of Oncology, Fuzhou General Hospital, Fuzhou, 350025, Fujian Province, China. fangwenzheng@hotmail.com.
刊名: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Vol.37 (4), pp.4803-11
来源数据库: PubMed Journal
DOI: 10.1007/s13277-015-4193-5
关键词: Gastric carcinomaImmunohistochemistryPrognosisP-4EBP1P-ACCP-AMPKaP-S6P-mTOR
原始语种摘要: Activation of AMP-activated protein kinase (AMPK) suppressed mammalian target of rapamycin (mTOR) pathway, resulting in impaired cancer cell proliferation. Two cohorts (50 and 1072 cases) of patients with resected gastric adenocarcinoma were enrolled in the study. Immunohistochemical staining for p-AMPKa, p-ACC, p-mTOR, p-S6, and p-4EBP1 was performed on the 50-patient cohort. Tissue microarray blocks containing samples from 1072 patients of Chinese ethnicity were used for the immunohistochemical detection of p-AMPKa and p-S6 levels. p-AMPK and p-ACC were frequently inactivated in both cohorts of gastric cancer samples, while p-mTOR, p-S6, and p-4EBP1 were frequently activated in the small cohort of gastric cancer. However, only levels of p-AMPKa and p-S6 were associated with the overall...
全文获取路径: PubMed  (合作)
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来源刊物:
影响因子:2.518 (2012)

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关键词翻译
关键词翻译
  • gastric 胃的
  • cancer 癌症
  • associated 相关的
  • prognosis 预报
  • cohort 伙伴
  • expression 表示
  • survival 生存
  • frequently 经常
  • resection 后方交会
  • rapamycin 雷帕霉素