Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients.
作者: Shi RuiWang Pei-YinLi Xin-YiChen Jian-XinLi YanZhang Xin-ZhongZhang Chen-GuangJiang TaoLi Wen-BinDing WeiCheng Shu-Jun
作者单位: 1Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
2Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Henan, China.
3University of South Florida, Tampa, FL, USA.
4Beijing Key Laboratory for Tumor Invasion and Metastasis, Cancer Institute of Capital Medical University, Beijing, China.
5Department of Biochemistry, Molecular Biology Capital Medical University, Beijing, China.
6Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China.
7Beijing Key Laborator
刊名: Oncotarget, 2015, Vol.6 (29), pp.26971-81
来源数据库: PubMed Journal
DOI: 10.18632/oncotarget.4699
关键词: Cancer prognosisCerebrospinal fluidExtracellular vesiclesGliomaHsa-miR-21
原始语种摘要: Glioma is a most common type of primary brain tumors. Extracellular vesicles, in the form of exosomes, are known to mediate cell-cell communication by transporting cell-derived proteins and nucleic acids, including various microRNAs (miRNAs). Here we examined the cerebrospinal fluid (CSF) from patients with recurrent glioma for the levels of cancer-related miRNAs, and evaluated the values for prognosis by comparing the measures of CSF-, serum-, and exosome-contained miR-21 levels. Samples from seventy glioma patients following surgery were compared with those from brain trauma patients as a non-tumor control group. Exosomal miR-21 levels in the CSF of glioma patients were found significantly higher than in the controls; whereas no difference was detected in serum-derived exosomal miR-21...
全文获取路径: PubMed  (合作)
影响因子:6.636 (2012)

  • glioma 神经胶质瘤
  • prognosis 预报
  • cerebrospinal 脑脊髓的
  • recurrence 循环
  • associated 相关的
  • tumor 肿胀
  • correlated 相关
  • metastasis 同质蜕变
  • brain 
  • survival 生存