|作者：||Wang Rongshen, Sun Jinfeng, Jin Mei, Ye Chao, Wang Jiaming, Jin Long, Ma Ying Jie, Zhou Wei, Li Gao|
1Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, P. R. China.
2Department of Pharmacy, Yanbian University Hospital, Yanji, P. R. China.
3Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian U
|刊名：||Natural product research, 2020, pp.1-10|
|关键词：||Rosaceae; Sanguisorba officinalis L.; Anti-complementary activity; Monoterpenoid glycoside; Phenolic glycoside;|
|原始语种摘要：||Sanguisorba officinalis L. is a traditional herbal plant that belongs to the genus Sanguisorba and the family Rosaceae. Two new phenolic glycosides ( 1-2 ), ten known phenolics ( 3-12 ), and six known monoterpenoid glycosides ( 13-18 ) were isolated from the roots of S. officinalis using silica gel column and preparative middle pressure liquid chromatography (MPLC). The chemical structures were elucidated based on extensive spectroscopic experiments, including 1D and 2D NMR as well as HR-ESI-MS, and comparison with those reported in the literature. Compounds 3-5 , and 13 were isolated from the Rosaceae family and compound 7 was obtained from the genus Sanguisorba for the first time. Additionally, all compounds were evaluated for their anti-complementary activities against the classical... pathway. Furthermore, compounds 1 , 5 , 9 , and 14 showed significant anti-complementary activities with the 50% haemolytic inhibition concentrations (CH50) values of 0.40 ± 0.03, 0.57 ± 0.01, 0.51 ± 0.07, and 0.53 ± 0.05 mM, respectively.|