Effects of celiprolol on cardiovascular reactivity to laboratory stressors in patients with hypertension.
作者: Cardillo CDegen CDe Felice FFolli G
作者单位: 1Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Rome, Italy.
刊名: Clinical pharmacology and therapeutics, 1992, Vol.51 (5), pp.555-61
来源数据库: PubMed Journal
原始语种摘要: An ideal antihypertensive drug should reduce blood pressure not only at rest but also during stressful situations. To test whether this criterion is fulfilled by celiprolol, a new beta 1-selective adrenergic blocker drug with peripheral vasodilating activity, we examined the effects of its oral administration on cardiovascular reactivity to laboratory stressors in 18 patients with essential hypertension, according to a placebo-controlled crossover design. In the 12 patients classified as "responders," celiprolol significantly reduced resting systolic and diastolic blood pressure (p less than 0.05 for both). Compared with placebo, celiprolol induced a blood pressure reduction from 179.4 +/- 16.9/119.5 +/- 12.4 mm Hg to 160.7 +/- 12.6/109.4 +/- 3.1 mm Hg during mental arithmetic; from 200.9...
全文获取路径: PubMed  (合作)
影响因子:6.846 (2012)

  • celiprolol 高脂肪肝
  • laboratory 实验室
  • hypertension 高血压
  • vasodilating 血管舒张的
  • induced 感应的
  • blood 血液
  • ergometry 测力学
  • handgrip 把手
  • pressure 压力
  • reduced 减缩的