Alpha-cells: Its Role as the Islet Harmonizer
作者: Nabil Kamal Elnaggar Mohamed Nabil Elnaggar
刊名: International Journal of Diabetes and Endocrinology, 2019, Vol.4 (4)
来源数据库: Science Publishing Group
DOI: 10.11648/j.ijde.20190404.13
关键词: Pancreatic Islet CellsB CellsAlpha CellsGlucagonGIP (Glucose-dependent Insulinotropic Polypeptide)GLP-1 (Glucagon-like Peptide 1)
原始语种摘要: It has long been thought that the alpha cells and its secretory products play an important role solely in maintaining euglycemia and preventing hypoglycemia through a contradictory action to the B cell’s insulin. The α-cell function is tightly regulated by various physiological inputs including systemic energy status, central and autonomic nervous systems, and the endocrine system. It is also an important amino acid sensor, glucagon blockade suppresses hepatic amino acid catabolism and increases the serum amino acid level. In addition to those controllers, the intra-islet microenvironment, where α-cells are located, has been recently revealed to be important in the regulation of the various cellular secretory functions including the overlapping of glucagon and insulin secretion through a...
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  • glucagon 高血糖素
  • hypoglycemia 低血糖
  • insulin 胰岛素
  • islet 
  • hormone 激素
  • secretion 分泌
  • glucose 葡萄糖
  • homeostasis 体内平衡
  • acetylcholine 乙酰胆碱
  • autonomic 自发的