Pharmacodynamic and Pharmacokinetic Studies on Tetracycline Hydrochloride in Rabbits
作者: Elsayed A. Abdel Aziz
刊名: Zagazig Veterinary journal, 2017(3)
来源数据库: Pak Publishing Group
DOI: 10.5281/zenodo.998935.
关键词: TetracyclineTissuesResiduesHPLCRabbits
原始语种摘要: Tetracycline is one of the most important groups of antibiotics that have harmful effects on the consumers, therefore the public health safety against its residues represents a significant issue. This study aimed to estimate the effect of tetracycline hydrochloride on some hematological parameters, kidneys function tests as well as liver and breast muscle enzymes with special reference to the supposed withdrawal time of this drug in different rabbits’ tissues (kidney, liver and muscles), following oral dose of tetracycline using High Performance Liquid Chromatography. Tetracycline was administrated to eighteen rabbits directly into the stomach at a dose of 35 mg/kg BW once daily for five successive days. Samples were collected on the 1 st , 3 rd, 7th , 14th , 21st and 28th days after the...

  • tetracycline 四环素
  • hematological 血液学的
  • muscles 筋肉
  • withdrawal 取消
  • hydrochloride 盐酸盐
  • liver 
  • stomach 
  • parameters 参数
  • significant 有效的
  • returned 退回