Contribution of germline TP53 variants and assessment of HER2 status among young breast cancer patients in Malaysia
作者: Shao Yan Lau Pei Sze Ng Joanna Lim Wei Xiong Wen Kah Nyin Lai Siti Norhidyu Hasan Daphne Shin-Chin Lee Sook Yee Yoon Cheng Har Yip Nur Aishah Mohd Taib Antonis Antoniou Alison Dunning Douglas Easton Soo Hwang Teo
刊名: Advances in Modern Oncology Research, 2017, Vol.3 (6)
来源数据库: PiscoMed Publishing Pte. Ltd
DOI: 10.18282/amor.v3.i6.262
关键词: TP53 variantBreast cancerLi-Fraumeni Syndrome (LFS)
原始语种摘要: Background: Li-Fraumeni Syndrome (LFS) is caused by a mutation in the TP53 tumour suppressor gene. This rare hereditary condition predisposes individuals to an increased risk of cancers including breast cancer in women at a relatively young age, which accounts for nearly 25%–30% of all LFS‑associated cancers. Studies have shown that breast tumours in women with a germline TP53 deleterious variants are associated with a human epidermal growth factor receptor 2 (HER2)-positive phenotype. Taken together, this study aimed to investigate the contribution of germline TP53 variants and its association with tumour HER-2 status in a cohort of young women with breast cancer. Methods: From 2002 to 2017, 4048 women with breast cancer treated at University Malaya Medical Centre or Sime Darby...
全文获取路径: PiscoMed Publishing  (合作)
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关键词翻译
关键词翻译
  • breast 胸部
  • sequencing 排序
  • nucleotide 核苷酸
  • status 状态
  • young 年轻的
  • among 在当中
  • assessment 评价
  • cancer 癌症
  • nonsense 无意义的
  • negative 负象