The advancements of genomics and data integration in sarcoma research
作者: Ricardo J. Flores Aaron J. Kelly Manjula Nakka Xiang Chen Jiayi Sun Tsz-Kwong Man
刊名: Advances in Modern Oncology Research, 2017, Vol.3 (4)
来源数据库: PiscoMed Publishing Pte. Ltd
DOI: 10.18282/amor.v3.i4.236
关键词: omicsgenomicssarcomassequencingmicroarraydata integrationbioinformaticsbig data
原始语种摘要: In the age of big data, genomics and clinical research have reached a crossroads. A wealth of data is being generated, but it is becoming increasingly complicated to analyze these data to extract meaningful results. The ability to understand biological systems holistically has unprecedented potential to transform how cancers are treated. Recent major advances leading biomedical research towards “systems medicine” have been fueled by high-throughput platforms, such as microarrays and next-generation sequencing, which can capture vast amounts of data in different genomic spaces. Unfortunately, because of high dimensionality and complex relationships among these data, inferring comprehensive and useful biological models has proven computationally and statistically challenging. However, novel...
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  • integration 集成
  • sarcoma 肉瘤
  • research 
  • sequencing 排序
  • evolution 进化
  • biological 生物学的
  • dimensionality 量纲
  • statistically 统计地
  • novel 长篇小说
  • these 这些的