The potential involvement of the cofactor of BRCA1 in hepatocellular carcinoma pathogenesis
作者: Aya Youssef Heba Shawer Alaa Afify Asma Amleh
刊名: Advances in Modern Oncology Research, 2016, Vol.2 (4)
来源数据库: PiscoMed Publishing Pte. Ltd
DOI: 10.18282/amor.v2.i4.129
关键词: COBRA1HCCHepG2SNUAP-1
原始语种摘要: The cofactor of BRCA1 (COBRA1), which also refers to negative elongation factor polypeptide B (NELF-B), is a negative elongation factor (NELF) subunit that has been implicated in the development and progression of several cancers. While reduced COBRA1 expression has been associated with metastatic breast cancer, COBRA1 negatively regulates the activator protein-1 (AP-1) complex, leading to the down-regulation of trefoil factor-1 (TFF1) expression in gastric cancer cell lines. The involvement of COBRA1 in hepatocellular carcinoma (HCC) tumor formation and progression is not known. Here, we investigated the expression of COBRA1, the AP-1 complex, and TFF1 in several HCC cell lines; ranging from low- to high-grade HCC cell lines generated from patients with different stages of the disease....
全文获取路径: PiscoMed Publishing  (合作)
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关键词翻译
关键词翻译
  • cofactor 辅助因子
  • expression 表示
  • hepatocellular 肝细胞性的
  • negative 负象
  • several 各自
  • expressed 榨出的
  • carcinoma 癌症
  • complex 超群
  • protein 蛋白质
  • lines 线型