The war against cancer: Suicide gene therapy
作者: Muzeyyen Izmirli Dilara Sonmez Bulent Gogebakan
刊名: Advances in Modern Oncology Research, 2016, Vol.2 (3)
来源数据库: PiscoMed Publishing Pte. Ltd
DOI: 10.18282/amor.v2.i3.103
关键词: suicide gene therapycancervector
原始语种摘要: The National Cancer Institute and the American Cancer Society announced that 1.6 million new cancer cases are projected to occur in the USA in 2016. One of the most innovative approaches against cancer is suicide gene therapy, in which suicide-inducing transgenes are introduced into cancer cells. When cancer treatments target the total elimination of tumor cells, there will be no side effects for normal cells. Cancer tissues are targeted through various targeted transport methods, followed by tissue-specific enzymes converting a systemically suitable prodrug into an active drug in the tumor. Suicidal genes are delivered by transporters, such as viral and non-viral vectors, into cancer cells. Suicide gene therapeutic strategies currently pursued are herpes simplex virus thymidine kinase...
全文获取路径: PiscoMed Publishing  (合作)

  • targeted 对准目标的
  • thymidine 胸腺嘧啶
  • suicide 自杀
  • prodrug 药物前体
  • varicella 水痘
  • zoster 带状疱疹
  • cells 麻风细胞
  • deaminase 脱氨酶
  • therapeutic 治疗的
  • cytochrome 细胞色素