ASSESSMENT OF THE PRODUCTION VARIABLES ON THE PELLETIZATION PROPERTIES OF MICROCRYSTALLINE CELLULOSE II (MCCII)
作者: John RojasDavid Correa
作者单位: 1Department of Pharmacy, School of Pharmaceutical and Food Sciences, University of Antioquia, Medellin, Columbia. jrojasca@gmail.com
刊名: International Journal of Pharmacy and Pharmaceutical Sciences, 2017, Vol.9 (10), pp.73-80
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijpps.2017v9i10.20580
原始语种摘要: Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid using the extrusion/spheronization technology.Methods: The effect of the spheronization rate and spheronization time was assessed by a response surface design. The shape descriptors and physical properties of pellets were taken as response variables. Approximately, 30 g of MCCII were hydrated, passed through a # 20 mesh sieve and spheronizated at frequencies of 6, 9 and 12 Hz and residence times of 15, 240 and 480 s in 9 experimental runs. In a separate experimental set, moisture levels of 25, 50, 75, 100 and 125% were employed at the optimal operating conditions of 6 Hz and 480 s. A microscopy analysis was used to evaluate the shape descriptors. Pellets properties such as compressibility, friability,...
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关键词翻译
关键词翻译
  • pelletization 成球
  • porosity 孔隙率
  • conditions 条件式
  • friability 松散性
  • level 水准
  • properties 道具
  • value 
  • cellulose 纤维素
  • shape 形状
  • augmented 增加的