DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF GEMCITABINE HYDROCHLORIDE IN BULK AND POLYMERIC NANOPARTICLES
作者: Taranjit KaurSukhjinder KaurParminderjit Kaur
作者单位: 1Rayat-Bahra Institute of Pharmacy, Bohan, Hoshiarpur. parminderkaur.pk67@gmail.com
刊名: International Journal of Applied Pharmaceutics, 2017, Vol.9 (5), pp.60-65
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2017v9i5.19726
原始语种摘要: Objective: The objective of the present work was to develop and validate a novel, specific, precise and reliable method for estimation of gemcitabine hydrochloride in bulk and polymeric nanoparticles using UV-visible spectroscopy method.Methods: The UV-Visible spectrophotometric determination was performed with double beam Systronics UV-visible spectrophotometer; model UV-2201 (India). The proposed methods were validated for various parameters like linearity, precision, accuracy, robustness, ruggedness, detection, quantification limits, and formulation analysis as per international conference on harmonization (ICH) guidelines.Results: The method was based on measurement of absorbance at wavelength maxima i.e. 267.2 nm, λmax of the drug in distilled water, phosphate buffer pH 6.8 and 7.4....
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关键词翻译
关键词翻译
  • develop 发展
  • harmonization 协调
  • ruggedness 强度
  • international 国际的
  • method 方法
  • robustness 坚固性
  • polymeric 聚合的
  • linearity 线性
  • precision 精度
  • hydrochloride 盐酸盐