| 作者： |
Bharat W. Tekade, Umesh T. Jadhao, Shruti G. Patil, Vijay R. Patil
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| 作者单位： |
1Department of Pharmaceutics, TVES’s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, (India). bharattekade@yahoo.co.in
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| 刊名： |
International Journal of Current Pharmaceutical Research, 2017, Vol.9 (6), pp.18-22 |
| 来源数据库： |
Innovare Academics Sciences PVT.Ltd. |
| DOI： |
10.22159/ijcpr.2017v9i6.23422 |
| 原始语种摘要： |
Objective: The objective of research work was to formulate and evaluate the floating drug delivery system containing Cefpodoxime Proxetil using polymer HPMC K4M, Guar Gum.Methods: Effervescent floating tablets containing Cefpodoxime proxetil were prepared by direct compression technique using varying concentrations of different grades of polymer.Results: Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110%. The floating time was found to be more than 12 H. floating lag time was found to be 10±2.99 second. Formulation batch F8 was selected as an optimum formulation, as possessing less disintegration time, higher water absorption ratio and good... content uniformity i.e. within acceptable limit.% drug release of formulation batch F8 was found to be 96.66% in 0.1 N HCL.Conclusion: The FT-IR studies of batch F8 was carried out which showed the peak values within the spectrum corresponding to the peak values of pure drug.
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