PHARMACOKINETIC PROFILE OF 75 MG CLOPIDOGREL IN PLASMA OF INDONESIAN HEALTHY SUBJECTS BY ULTRA HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
作者: Yahdiana HarahapGanesya Rita PutriHerman Suryadi
作者单位: 1Department of Bioavailability/Bioequivalence Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.. yahdiana03@yahoo.com
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (1), pp.331-334
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018.v10s1.73
原始语种摘要: Objective: This study aimed to determine clopidogrel in plasma to obtain its pharmacokinetic profile using ultra-high-performance liquidchromatography-tandem mass spectrometry (UPLC-MS/MS).Methods: Clopidogrel analysis was performed in vivo by UPLC-MS/MS using validated methods. Subjects received 75 mg clopidogrel, and plasmasamples were collected at 14 time points after 0 baseline (pre-dose): 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, 3, 4, 8, 12, 18, and 24 h.Results: A linear calibration curve was produced in the range of 20–5.000 pg/mL. This method fulfills the criteria for validation according to theEuropean Medicines Agency guidelines. The obtained pharmacokinetic profile of clopidogrel was as follows: Maximum concentration=1.146 ng/mL,time at maximum concentration (tmax)=1 h, half-life...
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关键词翻译
关键词翻译
  • TANDEM 美)天腾公司(主要生产容错型计算机
  • profile 纵断图
  • tandem 串联机
  • concentration 浓度
  • plasma 深绿玉髓
  • calibration 校准
  • tablet 药片
  • analysis 分析
  • liquid 液体
  • healthy 健康的