SENSITIVE SPECTROPHOTOMETRIC ASSAY OF MUSCARINIC RECEPTOR ANTAGONIST TOLTERODINE TARTRATE IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
作者: Ragaa El-sheikhWafaa S HassanAyman A GoudaMarwa M El-gabry
作者单位: 1Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt. aymangouda77@gmail.com
刊名: Asian Journal of Pharmaceutical and Clinical Research, 2017, Vol.10 (8), pp.346-352
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ajpcr.2017.v10i8.18794
原始语种摘要: Objective: Simple, sensitive, and accurate spectrophotometric methods have been developed for the assay of tolterodine tartrate (TOL) in bulk drugand pharmaceutical formulations.Methods: The proposed methods are based on oxidation reaction of TOL with a known excess of cerium(IV) ammonium sulfate as an oxidizing agentin acid medium followed by determination of unreacted oxidant by adding a fixed amount of dye, e.g., amaranth (AM), rhodamine 6G (Rh6G), andindigo carmine (IC) followed by measuring the absorbance at 520, 530, and 610 nm, respectively. The effect of experimental conditions was studiedand optimized.Results: The Beer’s law was obeyed in the concentration ranges of 1.0-10, 1.0-12, and 0.5-9.0 μg/mL using AM, Rh6G, and IC dyes, respectively, witha correlation coefficient ≥0.9995....
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关键词翻译
关键词翻译
  • oxidizing 氧化
  • ammonium 
  • respectively 分别
  • oxidation 氧化
  • excess 超量
  • values 价值观
  • standard 标准
  • reported 报告的
  • absorbance 吸光度
  • proposed 建议的