ANTIOXIDANT EFFECT OF POLYHERBAL FORMULATION IN ISOPRENALINE HYDROCHLORIDE INDUCED MYOCARDIAL INFARCTION IN RATS
作者: Kavitha P.Sowmia C.
作者单位: 1G and Research Department of Biochemistry, Dr.NGP Arts and Science College, Coimbatore, Tamilnadu 641048, India. kavirajan83@yahoo.com
刊名: International Journal of Pharmacy and Pharmaceutical Sciences, 2017, Vol.9 (10), pp.273-275
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijpps.2017v9i10.20310
原始语种摘要: Objective: Myocardial infarction (MI) continues to be a major public health problem in the world. The prepared polyherbal formulation (PHF) exhibit cardioprotective effects by several mechanisms. The objective of the research was to evaluate the antioxidant effect of a polyherbal formulation in isoprenaline hydrochloride (ISO) induced myocardial infarction in rats.Methods: Oxidative stress and myocardial infarction was induced by administration of isoprenaline hydrochloride (25 mg/kg) for 2 d. The degree of protection was determined by measuring the levels of lipid peroxidation (LPO), enzymatic antioxidants (superoxide dismutase-SOD, Catalase, Glutathione peroxidase) and non-enzymatic antioxidants (Vitamin C, E and reduced glutathione-GSH).Results: Two different doses (250 mg and 500...
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关键词翻译
关键词翻译
  • enzymatic 酶催的
  • hydrochloride 盐酸盐
  • antioxidants 抗氧化剂
  • formulation 配方
  • isoprenaline 喘息定
  • infarction 梗塞
  • induced 感应的
  • myocardial 心肌的
  • homogenate 均质
  • superoxide 过氧化物