EVALUATION OF ANTIDEPRESSANT ACTIVITY OF TAPENTADOL IN SWISS ALBINO MICE
作者: Pradeep BeNarendranath SShruthi KsShashikala GhKrishnagouda PatilLatha S
作者单位: 1Department of Pharmacology, J.J.M. Medical College, Davangere, Karnataka, India. pradeepbasetapla@gmail.com
刊名: Asian Journal of Pharmaceutical and Clinical Research, 2017, Vol.10 (8), pp.103-107
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ajpcr.2017.v10i8.17129
原始语种摘要: Objective: The aim of this study is to evaluate the antidepressant activity of tapentadol using forced swimming test (FST) and tail suspension test (TST) experimental models.Methods: A total of 36 Swiss albino mice (18 for each experimental model) were divided into 3 groups of 6 animals each. In both the experimental models, Group I received normal saline – 10 ml/kg (Control group), Groups II and III given tapentadol 20 mg/kg and tapentadol 40 mg/kg, respectively, for 7 days, intraperitoneally. On day 7, the drugs were given 40 minutes before conducting the experiment. The duration of immobility was noted and compared among all the 3 groups. The observations were analyzed using analysis of variance and Tukey’s post-hoc test.Results: The duration of immobility was significantly decreased...
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关键词翻译
关键词翻译
  • seconds 计秒
  • significant 有效的
  • duration 持续时间
  • antidepressant 抗抑郁药
  • received 接收
  • immobility 不动性
  • conducting 导电的
  • statistically 统计地
  • experimental 实验的
  • albino 白化体