DEVELOPMENT AND EVALUATION OF ANTI-ACNE GEL CONTAINING GARLIC (ALLIUM SATIVUM) AGAINST PROPIONIBACTERIUM ACNES
作者: Nyi Mekar SaptariniIrma Erika Herawati
作者单位: 1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Jl Raya Bandung Sumedang Km 21, West Java, Indonesia.. nyi.mekar@unpad.ac.id
刊名: Asian Journal of Pharmaceutical and Clinical Research, 2017, Vol.10 (8), pp.260-262
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ajpcr.2017.v10i8.19271
原始语种摘要: Objective: The aim of this study is to develop and evaluate the gel of garlic juice as anti-acne to facilitate the topical usage.Methods: The steps of this study consisted of extraction, gel formulations with various concentrations of carboxymethyl cellulose (CMC), and gel evaluation, i.e., organoleptic, viscosity, pH, skin irritation test, hedonic test, and anti-acne activity assay against Propionibacterium acnes.Results: The garlic juice contains alkaloids, saponins, tannins, monoterpenes, and sesquiterpenes. The different concentrations of CMC produce different physicochemistry properties of the gels. These properties were affected the gels stability, anti-acne activity, and the panelis perception on hedonic test.Conclusion: The garlic juice at 7.5% has anti-acne activity to P. acnes,...
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关键词翻译
关键词翻译
  • sesquiterpenes 倍半萜
  • saponins 皂甙
  • cellulose 纤维素
  • tannins 鞣酸类
  • alkaloids 生物碱类
  • garlic 大蒜
  • carboxymethyl 羧甲基
  • hedonic 快感的
  • activity 活度
  • topical 局部的