IN SILICO CHARACTERIZATION AND MOLECULAR MODELLING OF SODIUM-DEPENDENT SEROTONIN TRANSPORTER PROTEIN FROM HOMO SAPIENS
作者: Hina BansalNeetu Jabalia
作者单位: 1Department of Biotechnology, Amity University, Sector 125, Noida, Uttar Pradesh, India.. hbansal@amity.edu
刊名: Asian Journal of Pharmaceutical and Clinical Research, 2017, Vol.10 (8), pp.299-303
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ajpcr.2017.v10i8.18954
原始语种摘要: Objective: The objective of our investigation is to apply computational tools for a protein sodium-dependent serotonin transporter (SERT). It plays a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease, and depression-susceptibility. Although various conventional and experimental therapies have been directed for the treatment, still it needs attention for more effective treatments. Toward this pursuit, we performed in silico analysis of the protein using computational tools and servers.Methods: Homology modeling approach has been used to define the tertiary structure of the protein using SWISS-MODEL workspace. Modal validation was done to verify the generated modal. Furthermore, primary and secondary structural and functional analysis was performed to provide...
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关键词翻译
关键词翻译
  • protein 蛋白质
  • secondary 二次的
  • structural 构造
  • disorder 无序
  • serotonin 血清素
  • analysis 分析
  • computational 计算的
  • susceptibility 磁化率
  • Rampage 腾飞牌汽车
  • residues 残余物