FORMULATION AND EVALUATION OF ACECLOFENAC PRONIOSOME LOADED ORABASE FOR MANAGEMENT OF DENTAL PAIN
作者: G. V. RadhaK Trideva SastriP. PrathyushaP. BhanuJampala Rajkumar
作者单位: 1GITAM Institute of pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh State, India.. radhagadela@gmail.com
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (6), pp.204-210
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018v10i6.29143
原始语种摘要: Objective: The main motive is to develop proniosomes loaded orabase for enhanced permeation and prolonged release of aceclofenac for oro dental conditions.Methods: Various aceclofenac (ACL) proniosomal gels were formulated employing various surfactants, span 60 was superior and significant for loading into orabase. The formulations were scrutinized for entrapment efficiency, optical microscopy, in vitro diffusion and release studies, mucoadhesive strength, ex-vivo permeation studies and drug-excipient interactions were determined by FTIR spectroscopy.Results: Considering best entrapment efficiency with span 60 (97.60±1.85) and optimum vesicle shape, along with prolonged drug permeation (45% for 24 h) the formulation F(ACL)1 was selected and optimized for loading into orabase. The F(ACL)1...
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关键词翻译
关键词翻译
  • permeation 渗透
  • loaded 加负荷的
  • excipient 赋形剂
  • formulation 配方
  • entrapment 诱陷
  • release 释放
  • prolonged 持续很久的
  • loading 加负载
  • conditions 条件式
  • dental 齿骨