BIODEGRADABLE LIPOSOMES FOR ACYCLOVIR-GOLD NANOPARTICLES AS AN EFFICIENT CARRIERFOR ENHANCED TOPICAL DELIVERY
作者: Heba F. SalemSabry M. TamamSahar M. Lotayef
作者单位: 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Egypt. saharlotayef@gmail.com
刊名: International Journal of Pharmacy and Pharmaceutical Sciences, 2017, Vol.9 (8), pp.60-64
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijpps.2017v9i8.17243
原始语种摘要: Objective: Gold nanoparticles and nanoliposomes are effective new technology in delivering the bioactive agents and enhancing their performance by increasing the bioavailability. The goal of the present study was the formulation of liposome for the use as a carrier for nanogold conjugated with acyclovir (ACV), an antiviral drug, to enhance ACV delivery.Methods: The gold nanoparticles were used as a capping agent for ACV and sodium citrate was used as reducing agent for the gold. Transmission electron microscopy was used for characterization and to study the morphological and structural properties of drug-metallic nanostructures. Nanoliposomes were formulated using different molar ratios of a positive charge inducer (stearyl amine) or a negative charge inducer (diacetyl phosphate),...
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关键词翻译
关键词翻译
  • conjugated 共轭的
  • acyclovir 无环鸟苷
  • enhancing 增强
  • phosphate 磷酸盐
  • carboxylic 类羧酸的
  • amine 
  • antiviral 抗病毒的
  • inducer 诱导剂
  • particle 颗粒
  • sodium