EFFECT OF NANOCURCUMIN ON CISPLATIN-INDUCED ACUTE KIDNEY INJURY: A FOCUS ON NRF2 AND KEAP1
作者: Bashar Adi Wahyu PandhitaVivian SoetiknoMelva Louisa
作者单位: 1Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia.. vivian_09st@yahoo.com
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (1), pp.152-154
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018.v10s1.32
原始语种摘要: Objective: This study aimed to investigate the effect of nanocurcumin (NC) against cisplatin-induced acute kidney injury, focusing on Nrf2 and Keap1.Methods: Male Sprague-Dawley rats (n=23) were divided into five groups (Control, CP, CP+Cur, CP+50 NC, and CP+100 NC) and sacrificed 7 days aftertreatment. Whole kidneys were collected for reverse transcription polymerase chain reaction (RT-PCR) analysis of Nrf2 and Keap1.Results: There were no statistically significant differences in the RT-PCR results among the groups (p>0.05). However, Keap1 expression wasupregulated in rats treated with 100 mg of NC, which may have been caused by increased Nrf2 activation and activation of a negative feedback loop,which upregulated transcription of Keap1.Conclusion: NC increased Keap1 levels, but not...
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关键词翻译
关键词翻译
  • divided 分部联箱
  • increased 增加
  • investigate 
  • expression 表示
  • aftertreatment 后处理
  • transcription 地名转写
  • statistically 统计地
  • cisplatin 顺氯氨铂
  • negative 负象
  • chain