IN SILICO DOCKING ANALYSIS OF BIOACTIVE COMPOUNDS FROM CALOPHYLLUM INOPHYLLUM L. ETHANOL LEAF EXTRACT AGAINST EGFR PROTEIN
作者: Jaikumar KSheik Noor MohamedJohn Wyson WDeventhiran MBabu AAnand DSaravanan P
作者单位: 1P.G & Research Department of Botany, Ramakrishna Mission Vivekananda College, Mylapore, Chennai - 600 004, Tamil Nadu, India.. jaikumarjk555@gmail.com
刊名: Asian Journal of Pharmaceutical and Clinical Research, 2017, Vol.10 (8), pp.214-219
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ajpcr.2017.v10i8.18972
原始语种摘要: Objective: The objective of this study was to evaluate the effective new phytocomponents from Calophyllum inophyllum ethanol leaf extract against breast cancer target protein of Epidermal Growth Factor Receptor (EGFR) using in silico docking studies.Materials and Methods: The identification of compounds was done by GC-MS analysis. The in silico docking studies were carried out using Discovery Studio 4.0 software.Results: The GC-MS analysis of ethanol leaf extract revealed the presence of eleven compounds. The docking analysis have exhibited moderate to potent inhibition with a range of dock score 3 to 55. 2H-Benzo(cd) pyrene-2,6(1,H)-dione, 3,5,7,10-tetrahydroxy-compound showed the dock score of 55.427.Conclusion: The results revealed out that the compounds present in Calophyllum...
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关键词翻译
关键词翻译
  • tetrahydroxy 四羟(基)的
  • compound 复合物
  • eleven 十一
  • docking 靠泊
  • protein 蛋白质
  • ethanol 乙醇
  • anticancer 抗癌的
  • bioactive 对活质起作用的
  • score 得分
  • responsible 负责的