PICEATANNOL AMELIORATES CISPLATIN-INDUCED HISTOLOGICAL AND BIOCHEMICAL ALTERATIONS IN RATS KIDNEY
作者: Sara A. WahdanSamar S. AzabDoaa A. ElsherbİnyEbtehal El-demerdash
作者单位: 1Pharmacology & Toxicology Department, Faculty of Pharmacy, Ain shams University, Cairo, Egypt. ebtehal_dm@yahoo.com
刊名: International Journal of Pharmacy and Pharmaceutical Sciences, 2017, Vol.9 (10), pp.305-311
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijpps.2017v9i10.15518
原始语种摘要: Objective: The present study was designed to investigate the effect of different doses of piceatannol (PIC) on cisplatin-induced biochemical and histological alterations in rat kidney.Methods: Male Wistar rats received a single intraperitoneal (i. p.) injection of cisplatin (7 mg/kg). PIC was given in different daily doses (5, 10 and 20 mg/kg) i. p., for seven days, starting two days before cisplatin injection. Nephrotoxicity was evaluated by means of measurement of blood urea nitrogen (BUN), serum creatinine and histopathological examination of the kidney. We also investigated the antioxidant effect of the most effective dose of PIC by measuring reduced glutathione (GSH) and lipid peroxides levels. Moreover, the ability of PIC to affect nuclear factor kappa B (NF-kB) expression was...
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关键词翻译
关键词翻译
  • cisplatin 顺氯氨铂
  • significantly 较大地
  • starting 起动
  • PIC Particle In Cell method
  • injection 贯入
  • induced 感应的
  • glutathione 谷胱甘肽
  • creatinine 肌酸酐
  • compared 肿瘤和正常组织细胞周期的比较
  • tubular 管状的