EFFICACY OF IONIC LIQUID [MIM]BR-BASED MAE ON RESVERATROL AND PHENOLIC COMPOUNDS EXTRACTION FROM GNETUM GNEMON SEEDS AND THEIR DPP-4 INHIBITORY ACTIVITY
作者: Arif ArrahmanRezi Riadhi SyahdiHana PermatasariIntan Fikri Purnama SariAbdul MunÍm
作者单位: 1Department of Pharmaceutical-Medicinal Chemistry and Bioanalysis, Faculty of Pharmacy, Universitas Indonesia, Depok 16424,. munim@farmasi.ui.ac.id
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (1), pp.168-171
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018.v10s1.36
原始语种摘要: Objective: This study aimed to determine the inhibitory activity of 1-butyl-3-methylimidazolium bromide ([bmim]Br) extracts of melinjo seeds(Gnetum gnemon) on dipeptidyl peptidase-4 (DPP-4).Methods: Melinjo seeds were extracted by a [bmim]Br microwave-assisted method using various extraction parameters and the inhibitory activityof DPP-4 of all extracts was determined in 96-well microplates using Cayman inhibitor screening assay. Determination of trans-resveratrol contentwas conducted using a reverse-phase high-performance liquid chromatography method. The total phenolic content was determined using a 96-wellmicroplate reader. Data analysis for the determination of the optimal extraction conditions was developed by response surface methodology.Results: The extract obtained from the third...
全文获取路径: IAS  (合作)
分享到:

×
关键词翻译
关键词翻译
  • 测定 肽酶
  • conditions 条件式
  • inhibitory 禁止的
  • determine 决心
  • conducted 有陪同的
  • extraction 提取
  • extracts 摘记
  • gallic 制图布
  • optimal 最佳的
  • peptidase 肽酶
  • determination 肽酶