ENHANCEMENT OF SOLUBILITY AND DISSOLUTION OF IBUPROFEN BY SOLID DISPERSION TECHNIQUE AND FORMULATION OF SUSTAINED RELEASE TABLETS CONTAINING THE OPTIMISED BATCH OF SOLID DISPERSION
作者: Abhik KarAbdul Baquee Ahmed
作者单位: 1Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati 781017, Assam. abhik666.ak@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2017, Vol.9 (5), pp.37-44
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2017v9i5.22134
原始语种摘要: Objective: The present study was aimed to enhance the solubility of poorly water soluble drug Ibuprofen using solid dispersion technique and to develop sustained release tablets containing solid dispersion granules of the optimized batch. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-inflammatory propertiesMethods: Solid dispersions of Ibuprofen were prepared by using PEG 20000 and Poloxamer 407 in different weight ratios by fusion and solvent evaporation method. Drug-carrier physical mixtures were also prepared. Solid dispersions were characterized by saturation solubility, drug content, in vitro dissolution, FTIR and DSC analysis. Solid dispersion formulation, SDF9 (PEG 20000 and Poloxamer 407, 1:3:3) prepared by solvent evaporation...
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关键词翻译
关键词翻译
  • granules 粒剂
  • solubility 溶度
  • formulation 配方
  • batch 一批
  • aqueous 水的
  • kinetics 动力学
  • solid 固体
  • release 释放
  • promising 前提
  • tablets 平片体