DIFFERENT EXPERIMENTAL MODELS USED TO INDUCE DIABETES MELLITUS IN RODENTS: A REVIEW
作者: RESHMI CHAKRABORTYABDUL BAQUEE AHMEDDIPANKAR SAHA
作者单位: 1Girijananda Chowdhury Institute of Pharmaceutical Sciences, Guwahati, Assam, India 781017. reshmi.c94@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2019, pp.60-62
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2019v11i4.34952
原始语种摘要: Diabetes is a metabolic disease characterized by the presence of hyperglycemia resulting from either defects in insulin secretion or action or both. Various processes are involved in the development of diabetes. These range from autoimmune destruction of the insulin-producing cells, β-cells of the pancreas, a dysfunction of the pancreatic β-cell, and impaired insulin action through insulin resistance. Experimental diabetes in animals are widely induced by administration of alloxan and streptozotocin at a proper dose. The mechanism of their action in pancreatic β-cells has been extensively investigated. Reactive oxygen species are responsible for the cytotoxic action of both these diabetogenic agents. However, the source of their generation is different in the case of alloxan (ALX) and...
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关键词翻译
关键词翻译
  • streptozotocin 链脲佐菌素
  • insulin 胰岛素
  • diabetes 糖尿病
  • diabetogenic 致糖尿病的
  • alloxan 阿脲
  • hyperglycemia 高血糖
  • impaired 受损
  • circumference 圆周
  • administration 管理
  • intake 收气